Drop in a sequence (FASTA, GenBank, or just paste it in) and see every base at native resolution. No tiling, no downsampling. The transcript becomes something you can actually hold and trust.
02 Annotate
Features and modified bases, layered in context.
Mark features, regions, and modified positions on one shared coordinate space. Click any base and see its context at once: its feature, its place inside a hairpin.
03 Fold
Secondary structure, straight from the engine.
Thermodynamic folding: minimum free energy and partition function. Hairpins draw themselves, and base-pair probabilities and ΔG come from the same engine.
04 Design
From sequence to oligo, without leaving the page.
Select a region, design primers and antisense oligos, and check Tm and structure on the same engine that folds. The transcript becomes a document you can author against.
The desktop app
One surface. Many tracks. On your machine.
nuvekta runs natively on macOS and Windows, with Linux to follow. Your sequences, structures, and annotations live on one surface, and it works offline. Built in React, TypeScript, and Tauri, with a custom canvas-and-SVG renderer.
nuvekta · synNGS-mRNA-Δ04
Views
Sequence
Structure
Plasmid
Enzymes
Features
Alignment
Primers
ASO Design
1306090120150180
engine foldReading
Ψ
Ψ
readingΔG resolves when the fold completes
Minimum free energy · engine fold
ΨpseudouridineChecked against the base it sits on
Arc2D
Structure Viewer
Ensemble & Sampling
Modified-Base Foldingm1Ψ
Pseudoknots
Circular RNA
Melting & Temperature
Chemical Probing
Inverse Folding
ASO & Duplex Design
Primer & Oligo Design
Compare
A stylized illustration of the workspace, not a screenshot.
Platform
Everything a sequence wants to be.
Sequence Viewer Live
Base-accurate rendering. Drag to select, click to annotate, jump anywhere. Multiple tracks sharing one coordinate space.
Structure Viewer Live
Secondary structure in 2D, with planar, circular, and linear layouts. Fold it, melt it by temperature, inspect any base, with a fast approximate mode for transcripts too long to fold exactly. ΔG and base pairs come from the engine.
Ensemble & Sampling Live
Base-pair probabilities, centroid structures, and positional entropy — structure prediction with a confidence view rather than one line of dot-bracket. Suboptimal structures and Boltzmann samples for sequences without one dominant fold.
Pseudoknots Live
Detection of H-type pseudoknots and kissing-loop motifs, and a pseudoknot-aware folding mode for structures a nested model cannot represent.
Circular RNA Live
Genuine circular folding, ensemble analysis, accessibility, and sampling — not a linear sequence joined end to end.
Compare Live
Fold up to six variants side by side in linked panels — mutations, or one sequence across several temperatures. Structures are held in a consistent orientation, so a change in shape is attributable to a change in sequence rather than a redrawn layout.
Publication Figures Live
Export as SVG or PNG at publication resolution, sized to a single or double journal column, with panel letters, arrows, and a caption. Generated in a print theme, not a screenshot of a dark interface.
Modified-Base Folding Live
Fold RNA with modified nucleotides like m1Ψ, pseudouridine, m6A, and inosine — the chemistry behind modified mRNA therapeutics and ADAR editing. Modifications are checked against the base they sit on before they can change a number.
Chemical Probing Live
Import SHAPE, DMS, or 2A3 reactivity and fold with it as an experimental restraint. Every profile is checked against your sequence — including how much of it is actually covered — before it can influence a structure.
Melting & Temperature Live
Melting temperatures and melt curves from the partition function, so you can see how a structure opens as the temperature climbs.
Inverse Folding Live
Draw the structure you want and search for sequences that fold into it, scored on the same thermodynamic engine that verifies the result.
Primer & Oligo Design Live
Design primers over any region with Tm, GC, hairpin, and dimer QC, then check the oligo's own structure on the engine that folds the target.
ASO & Duplex Design Live
Walk antisense oligos across a transcript and rank candidates on accessibility-corrected binding thermodynamics, not complementarity alone. Gapmer construction with selectable wing chemistries, off-target screening against a transcriptome you supply, and export in IDT, Twist, or GenScript order format.
Plasmid, Enzymes & Cloning Live
Circular maps with features in place, restriction analysis with cut sites on the same coordinates, and simulated gels. Four assembly methods — restriction/ligation, Gibson, Golden Gate, and Gateway — with junction thermodynamics and quality flags.
Sequence Alignment Live
Align two sequences and compare them base by base, global (Needleman–Wunsch) or local (Smith–Waterman), with an identity score and a dot-plot view.
Construct Workbench Live
Assemble an mRNA construct from its parts — 5′ UTR, CDS, 3′ UTR, tail — reorder them, edit any segment, and fold the whole molecule rather than the piece you just changed.
File Formats Live
Open FASTA, GenBank, SnapGene, ApE, CT, BPSEQ, and dot-bracket, plus the application’s own project format. Export to those, plus CSV, HELM for modified oligos, and figure formats.
Early access
Want in early?
We're onboarding a small group of early users: RNA labs, oligo and mRNA teams, and anyone who lives in sequence files. Leave your email and we'll reach out as the platform opens up.